First LSP Publication for Adler-Ramm – A quantitative approach to screen for kidney toxic compounds in vitro
Drugs and environmental chemicals are a common cause of kidney injury in humans, which poses a significant health burden for patients and a financial risk for pharmaceutical companies. However, there is still no regulatory accepted or validated in vitro model available to screen for kidney toxicity. In this signature paper for the toxicology field, we demonstrate the 2 things that are crucial to make accurate predictions about toxicity: an extensively characterized primary human kidney cell system, and a sensitive and specific biomarker of toxicity. The subsequent development of a high-throughput assay now allows, for the first time, rapid and robust screening of kidney toxic compounds to support chemical risk assessment and facilitate elimination of drug candidates early in the process before reaching humans.