News & Events Archive

HiTS Seminar: Nathanael Gray, PhD, 10:00 am, Thursday, October 11, 2018 October 4, 2018 -   Nathanael Gray, Ph.D. Dana-Farber Cancer Institute   Targeted Protein Degradation as a New Drug Development Strategy   10:00 am – 11:00 am Thursday, October 11, 2018 Harvard Medical School 200 Longwood Avenue Warren Alpert Bldg, 5th Floor, Room 563 Boston, MA 02115 Hosted by Kenichi Shimada, Ph.D.
HiTS Seminar: Dave Mellert, PhD, 10:00 am, Thursday, September 20, 2018 September 7, 2018 -   Dave Mellert, Ph.D. The Jackson Laboratory   Data Management for Data Science at The Jackson Laboratory Research data are usually collected with a specific question in mind and are thus most often managed and stored in a manner that makes reuse difficult or impossible. At the same time, the world is seeing an explosion […]
Ben Gyori named 2018 DARPA Riser September 6, 2018 - Benjamin M. Gyori, Ph.D., A Research Scientist in Therapeutic Science was selected as one of 50 DARPA Risers: up and coming early career investigators with the potential to perform innovative research at the frontiers of science and technology relevant to the mission of DARPA. As a DARPA Riser, Ben will attend DARPA’s 60th Anniversary Symposium […]
New NSF awards support the creation of bio-based semiconductors July 24, 2018 - Semiconductor synthetic biology promises to exceed limits of current data storage and processing methods Dr. Eduardo Sontag (Harvard Medical School Laboratory of Systems Pharmacology (LSP) Member, professor of Bioengineering and Electrical and Computer Engineering at Northeastern University) has been awarded, in collaboration with Dr. Chris Voigt from MIT and Dr. Kate Adamala from the University […]
HiTS Seminar: Stuart Schreiber, PhD, 10:00 am, Thursday, May 17, 2018 May 7, 2018 -   Stuart Schreiber, Ph.D. Broad Institute and Harvard University   Chemical Biology-based Approach to Understanding and Overcoming Resistance of Cancers to Therapies The ability of cancer cells to resist apoptotic death induced by radiation, chemotherapy, targeted therapies and immunotherapy has been a primary impediment to achieving long-lasting clinical responses. Cancer resistance is often studied through […]
HiTS Seminar: Bissan Al-Lazikani, PhD, 10:00 am, Tuesday, March 20, 2018 March 15, 2018 - Bissan Al-Lazikani, PhD Head of Data Science, Institute of Cancer Research, UK   Integrative Big Data for Cancer Drug Discovery and Individualised Therapy Advances in technology are enabling unprecedented systematic mapping of disease mechanisms. To fully exploit this wealth of knowledge in advancing cancer therapy, we must develop integrative ‘Big Knowledge’ approaches to inform drug […]
HiTS Seminar: Neal Rosen, MD, PhD, 11:00 am, Thursday, February 8, 2018 February 1, 2018 - Neal Rosen, MD, PhD Memorial Sloan Kettering Cancer Center Mutant Allele-specific Oncoprotein Function – Basic and Translational Implications 11:00 am – 12:00 pm Thursday, February 8, 2018 Harvard Medical School 200 Longwood Avenue Warren Alpert Bldg, 5th Floor, Room 563 Boston, MA 02115
Combination Rethink: “Bet Hedging” Explains the Efficacy of Many Combination Cancer Therapies December 14, 2017 - Benefits of many cancer drug combinations not due to interactions between drugs, but to a form of bet hedging At a glance: Survival benefits of many cancer drug combinations are not due to drug synergy, but to a form of “bet hedging.” Combination treatment gives each patient multiple chances of responding to at least one […]
HiTS Seminar: Juliet Williams and Hui Gao, 10:00 am, November 16, 2017 November 2, 2017 - Juliet Williams, Ph.D. and Hui Gao, Ph.D. Novartis Institutes of Biomedical Research 10:00 am – 11:00 am Thursday, November 16, 2017 Harvard Medical School 200 Longwood Avenue Warren Alpert Bldg, Room 563 Human Clinical Trials in Mice: Modeling Inter-patient Response Heterogeneity in PDXs Less than 10% of molecules which enter oncology trials become approved drugs. […]
Seminar by Joshua Apgar, Ph.D., 10:30am, September 14, 2017 September 7, 2017 - Joshua Apgar, Ph.D. Co-founder and CSO, Applied BioMath “Model Aided Drug Invention: Modeling Impact on Pharmaceutical R&D Applied BioMath Introduction and Case Studies” 10:30 AM Thursday, September 14, 2017 Harvard Medical School, Warren Alpert Bldg., Room 563
Seminar by C. Glenn Begley – 11am, 6/27/2017, WAB563 June 22, 2017 - C. Glenn Begley, MBBS, PhD, FRACP CEO, BioCurate Pty Ltd, Parkville, Australia “10% of the Time it Works Every Time” or How to Recognize Sloppy Science 11:00 AM Tuesday, June 27, 2017 Harvard Medical School, Warren Alpert Bldg., Room 563 As scientists and physicians, we all want to make a difference. We all want to […]
Cory Gerlach published in STAT-news! May 1, 2017 - Science isn’t dead in Washington. At least not yet  
HiTS Annual Symposium March 27, 2017 - _________________________________________________________________________________________________________ Tuesday, December 13, 2016 Cambridge Innovation Center, 20th floor, 50 Milk St, Boston, MA   8:00 – 8:45am Registration/Breakfast 8:45 – 9:00am Welcome Remarks – Peter Sorger, Head of Harvard Program in Therapeutic Science, Otto Krayer Professor of Systems Pharmacology, Harvard Medical School 9:00 – 10:00am Keynote Talk – Jeremy Jenkins, Director, Head of […]
Discovery and Validation of Biomarkers 2017 February 28, 2017 - A workshop on the development and use of biomarkers, regulation, and therapeutic innovation Hosted by Harvard Medical School, Harvard Business School, and the Kennedy School of Government April 3, 2017 Batten Hall Room 302, Harvard Business School Agenda 08:30-08:35 Introductory Remarks Aaron Kesselheim, M.D., J.D., Director of the Program On Regulation, Therapeutics, And Law Division of […]
Harvard-MIT Regulatory Science Symposium February 27, 2017 - Harvard-MIT Center for Regulatory Science Annual Symposium March 7, 2017 American Academy of Arts and Sciences | 136 Irving St. Cambridge MA   The Harvard-MIT Center for Regulatory Science is hosting industry-academic-FDA meetings in the Spring of 2017 to identify areas of regulatory science where a private-public partnership can make significant progress toward addressing a […]
Publication by Jones et al. in Nature Chemical Biology! November 1, 2016 - “Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation” Doug Jones, Annie Jenney, Jennifer Swantek, John Burke, Douglas Lauffenberger, Peter Sorger
Postdoctoral Position in Computational Biology at Celgene (Seattle, WA) August 5, 2016 - We seek a talented, collaborative interdisciplinary scientist to catalyze the development and application of computational approaches for the analysis of high-dimensional cell and molecular profiling data and integrative modeling of multiscale dynamical biological systems. The successful candidate will work on computational analysis of large multi-omics datasets (including genomics, transcriptomics, proteomics, and phenomics) and mathematical modeling […]
Congratulations to Mariana Cárdenas-González whose work has been featured in ScienceDaily and many more! July 21, 2016 - We are proud to announce that Mariana Cárdenas-González and the Vaidya Lab’s research on kidney toxins and early indications of kidney injury in children has been featured in ScienceDaily and EurekAlert as well as the websites of Harvard Medical School and Brigham and Women’s Hospital!
Murat Cokol Featured on the Cover of “Molecular Systems Biology” May 31, 2016 -   About the Cover Chemogenomics and orthology‐based design of antibiotic combination therapies
Research team led by Peter Sorger published in Nature Methods! May 3, 2016 - Congratulations to Mirra Chung, Marc Hafner, Mario Niepel and Peter Sorger for their discoveries on improved methods for quantifying how sensitive cells are to cancer drugs. To read more about their findings within Nature Methods Journal, please click here
Mark your calendars! Registration opens April 11th for the IDP Session! March 23, 2016 - The Office for Postdoctoral Fellows (OPF) upcoming IDP session is detailed below.   The Individual Development Plan: Maximizing Your Postdoc Training at HMS When: Wednesday, May 11, 2016 | 1:00-3:00pm Where: Gordon Hall, Bibring Room, 2nd Floor (MAP) Featured Speaker: James Gould, PhD, Director, HMS/HSDM Office for Postdoctoral Fellows Workshop Description:  The postdoc pursuit of […]
QSP-SB Industry & Academia Symposium January 21, 2016 - This symposium is a seminar series for presenting, learning, and discussing quantitative systems pharmacology (QSP) and systems biology (SB) topics. The goal of this event is to foster an active community of industry and academic participants interested in these topics, and create a forum for sharing our successes and challenges. DATE: Tuesday February 9, 2016 […]
Oliver Jonas Seminar January 12, 2016 -
Congratulations to Nienke Moret for being nominated to speak at the Keystone Symposium! December 8, 2015 - It is our pleasure to announce that graduate student Nienke Moret has been nominated to speak at the Keystone Symposia on Systems Immunology: From Molecular Networks to Human Biology. She will be speaking about methodical advances in systems immunology and focusing in on controlling regulatory T cell heterogeneity by chemical modification of signaling pathways. The […]
Congratulations to Mira Pavkovic for Winning the DFG Fellowship! December 7, 2015 - Mira received a very competitive and prestigious 2-year postdoctoral fellowship from Deutsche Forschungsgemeinschaft (DFG), German Research Foundation. This will allow Mira to investigate miRNAs as translational and mechanistic biomarkers for human kidney toxicity. The DFG is the largest independent research funding organization in Germany and encourages early career researchers to engage independently in research from […]
HiTS Fall Symposium 2015 September 25, 2015 - The HiTS Fall Symposium • Thursday, October 22, 2015 The American Academy of Arts & Sciences • 200 Beacon St, Somerville, MA Download the electronic version of the HiTS Fall Symposium Program Book here! 8:30 – 9:00 Registration and light breakfast 9:00 – 9:15 Welcome Remarks – Peter Sorger †, Head of the Program in […]
LSP on NPR August 10, 2015 - LSP’s work towards reinventing drug discovery was profiled on NPR on Monday, August 10th. To read the whole story click here:  
First LSP Publication for Adler-Ramm – A quantitative approach to screen for kidney toxic compounds in vitro July 21, 2015 -   Drugs and environmental chemicals are a common cause of kidney injury in humans, which poses a significant health burden for patients and a financial risk for pharmaceutical companies. However, there is still no regulatory accepted or validated in vitro model available to screen for kidney toxicity. In this signature paper for the toxicology field, […]
HiTS Spring Symposium 2015 May 11, 2015 - The HiTS Spring Symposium will take place on Friday, June 5, 2015 at the TMEC Amphitheater/Atrium. Attendance at the Symposium will be comprised of LSP faculty, fellows, students and Therapeutics Graduate Program students. In addition to our community, we will be inviting our partners from MGH, DFCI, Biogen Idec, Merck, Novartis and other institutions. We […]
HiTS Quarterly Newsletter March 13, 2015 - HiTS Newsletter – Second Quarter
Systems Biology of Human Disease 2015 – Travel Stipend Application March 13, 2015 - The International Conference on Systems Biology of Human Disease (SBHD) is a transatlantic event and communication platform for scientific exchange between the United States and Germany. It takes place alternately between the two countries. SBHD 2015 is continuing a conference series launched by Peter Sorger and colleagues from Harvard Medical School some years ago. The […]
Call for Proposals: Geneva workshop on the ethics of clinical translation February 10, 2015 - Call for Proposals – Making sense of clinical translation  
21st Century Cures Publishes Draft Proposals for Innovation Reform January 28, 2015 - The 21st Century Cures Initiative from the House Energy and Commerce Committee has published a discussion document outlining the content of proposals that may appear in legislation later this year.  The document proposes new ways to involve patients in the FDA’s regulatory process, and creates incentives for data sharing and research into complex diseases.  You […]
Bioinformatician in Functional Genomics at Harvard Medical School January 15, 2015 - Bioinformatician in Functional Genomics at Harvard Medical School We are seeking a PhD-level bioinformatician with experience in functional genomics analysis and software development to provide informatics support for research projects using functional genomic and proteomic strategies (in particular CRISPR/Cas9, RNAi and mass spec) and to help establish and coordinate a new Bioinformatics Working Group at […]
Mohammed AlQuraishi et al. publishes first LSP Publication in Nature Genetics November 6, 2014 - Mohammed AlQuraishi et al. publish first Laboratory of Systems Pharmacology publication in Nature Genetics, A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks.
Therapeutics Graduate Program Application is Due November 1st, 2014 October 23, 2014 - The Harvard Therapeutics Graduate Program application is due on November 1st 2014. All G1 and G2 students from any HILS program are eligible. Applicants will be interviewed in November and students will be notified of acceptance to the program in early December 2014. For more information contact Dr. Catherine Dubreuil: Download the Application here: Therapeutics Grad […]
Register Now! Director of Microscopy, Jennifer Waters will give Flourescence Microscopy Workshop, Oct. 17th October 10, 2014 - Register now for Flourescence Microscopy Workshop Fluorescence Microscopy Workshop Friday, October 17, 2014 10:00 AM – 4:00 PM (Eastern Time) Nikon Imaging Center at Harvard Medical School LHRRB Room 113 Harvard Medical School Boston, Massachusetts 02115 United States This workshop teaches fluorescence microscopy using lecture and hands-on laboratory exercises. We cover theoretical and practical information that […]
Aaron Kesselheim quoted in The New York Times October 10, 2014 - HiTS Faculty, Aaron Kesselheim quoted in The New York Times: “Financial Ties Between Doctors and Health Care Firms are Detailed”
HiTS Workshop on Computational Biology October 10, 2014 - HiTS Workshop in Computational Biology December 1st, 2014 – 1:00pm-6:00pm Jeffrey Modell Immunology Center Room 100A The workshop will focus on highlighting projects, resources, and techniques in bioinformatics that span genomics, image analysis, drug studies, proteomics, and machine learning applications.  To cover as much ground as possible, talks will be limited to 10 minutes. There will […]
The first quarterly HiTS Newsletter is now online! October 10, 2014 - The newsletter will highlight new developments in HiTS, describe new project funding, and profile investigators and students associated with the Laboratory of Systems Pharmacology.  To view the latest edition, open this news item and click on the link below to download a copy: HiTS Newsletter Oct-Dec 2014-Final
HiTS will host a Workshop in Computational Biology in December October 9, 2014 - Details of the event here and more soon to follow…
HMS Lab Grants to Support Computational Methods Development for Systems Pharmacology October 3, 2014 - HMS Lab Grants to Support Computational Methods Development for Systems Pharmacology Genome Web, September, 19 2014    
HiTS awarded over $30M in funding September 15, 2014 - HiTS awarded over $30M in funding HMS news, September, 2014  
UCI announces Systems Biology short course during January Session 2015 September 11, 2014 - Annual short course is being offered from University of California Irvine in January 2015 in “Systems Biology: Morphogenesis & Spatial Dynamics” There are tuition/travel fellowships available, the application deadline for fellowship support is October 3, 2014.
LINCS (Phase II) Center in HiTS is funded with a $12.8 Million grant from NIGMS September 5, 2014 - The overall goal of the HMS LINCS Center is to delineate the fundamental principles of cellular response to drugs and toxins at the level of single-cells and cell populations and to make response data routinely available on the web. The Center will develop, test and apply diverse measurement and computational methods and use these to […]
HiTS wins $3 Million Grant from DARPA “Big Mechanism” Initiative September 5, 2014 - The grant will allow HiTS scientists to participate in a nationwide consortium that will build advanced algorithms to accumulate and make sense of the vast biomedical literature databases on the internet.  The new system will learn from the literature and become a self-updating resource for understanding and hypothesis creation across all domains, beginning with cancer […]
HiTS is hiring a Data Curator and Project Manager for our NIH LINCS and DARPA projects. August 19, 2014 - There is an exciting new opportunity to join the LSP as a Data and Project Manager and contribute to two large projects sponsored by the NIH and DARPA!  View  posting here.
HiTS hosts Regulatory Science nano course on Challenges in Drug Evaluation and Regulatory Science: Application to Multiple Sclerosis June 25, 2014 - June 19th 2014, 1pm-6pm – Join HiTS as they host a Regulatory Science nano course on Challenges in Drug Evaluation and Regulatory Science: Application to Multiple Sclerosis. It will be held at HMS in the Cannon Room, Building C.
The 21st Century Cures Initiative to host Roundtable tomorrow (June 24th) on Digital Health Care June 23, 2014 - The Energy and Commerce Committee of the US House of Representatives is holding a Roundtable tomorrow at 10am to discuss digital healthcare and regulatory changes that will be helpful to accelerate the development of new medicines.  Watch the roundtable online here:
HiTS hosts Regulatory Science nano course on Challenges in Drug Evaluation and Regulatory Science: Application to Multiple Sclerosis June 12, 2014 - June 19th 2014, 1pm-6pm – Join HiTS as they host a Regulatory Science nano course on Challenges in Drug Evaluation and Regulatory Science: Application to Multiple Sclerosis. It will be held at HMS in the Cannon Room, Building C.
HiTS Faculty Leads a 4-day course in Biomarkers May 23, 2014 - Biomarkers Under the Scope – Harvard Catalyst course explores burgeoning field of study
Head of Toxicology for HiTS Wins Society of Toxicology Leading Edge in Basic Science Award May 6, 2014 -  Dr. Vishal S. Vaidya Harvard Professor Wins Society of Toxicology Leading Edge in Basic Science Award  Reston, Va.; March 17, 2014 — In honor of discoveries that illuminate the heart of toxicology, the Society of Toxicology (SOT) presents Harvard Medical School’s Vishal S. Vaidya, PhD, with the 2014 SOT Leading Edge in Basic Science Award. […]
HiTS Sponsors “Systems Biology of Human Disease” March 20, 2014 - HiTS is sponsoring the Systems Biology of Human Disease conference to be held in Boston on June 17-19, 2014.  
Call for Postdoctoral Fellowship Applications January 20, 2014 - The Harvard Medical School/Brigham and Women’s Hospital Program On Regulation, Therapeutics, And Law (PORTAL). The deadline is February 14, 2014.  For further information,
Laboratory of Systems Pharmacology Open! October 20, 2013 - As of October 2013, The Laboratory of Systems Pharmacology is open for business. The LSP has opened its doors in temporary space. Twelve postdocs, students and staff members from four institutions are currently working the lab.  The lab will be moving into it’s permanent space in April of 2014.  
Fallahi-Sichani et al. published in Nature Chemical Biology September 30, 2013 - The paper Metrics other than potency reveal systematic variation in responses to cancer drugs by Fallahi-Sichani et al. published in Nature Chemical Biology.  
Laboratory of Systems Pharmacology Construction to Begin August 1, 2013 - August – 2013. Preliminary architectural plans for the new Laboratory of Systems Pharmacology have been completed and construction documents are currently being prepared. Construction is scheduled to begin later in 2013 with occupancy in Spring, 2014.  
Systematic Drug Discovery July 21, 2013 - Systematic Drug Discovery Harvard Magazine, July 2013
State commits $9 million in capital grant funding for life sciences April 21, 2013 - State commits $9 million in capital grant funding for life sciences BBJ, April 2013
Harvard Med. School Granted $5M for Systems Pharmacology Lab April 13, 2013 - Harvard Med. School Granted $5M for Systems Pharmacology Lab Cantabrigia, 8 April 13