2014 LSP Publications

 

A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks. AlQuraishi, M., Koytiger, G., Jenney, A., MacBeath, G., and Sorger, P.K. (2014). Nat. Genet. 46, 1363–1371  View PDF

Hydrolysis of 2’3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Li, L., Yin, Q., Kuss, P., Maliga, Z., Millán, J.L., Wu, H., and Mitchison, T.J. (2014). Nat. Chem. Biol. 10, 1043–1048  View PDF

A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Gujral, T.S., Chan, M., Peshkin, L., Sorger, P.K., Kirschner, M.W., and MacBeath, G. (2014). Cell 159, 844–856  View PDF

MicroRNA-155 deficient mice experience heightened kidney toxicity when dosed with cisplatin. Pellegrini, K.L., Han, T., Bijol, V., Saikumar, J., Craciun, F.L., Chen, W.W., Fuscoe, J.C., and Vaidya, V.S. (2014). Toxicol. Sci. 141, 484–492  View PDF

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress. Foijer, F., Xie, S.Z., Simon, J.E., Bakker, P.L., Conte, N., Davis, S.H., Kregel, E., Jonkers, J., Bradley, A., and Sorger, P.K. (2014). Proc. Natl. Acad. Sci. U. S. A. 111, 13427–13432  View PDF

Failure analysis of clinical trials to test the amyloid hypothesis. Hyman, B.T., and Sorger, P. (2014). Ann. Neurol. 76, 159–161 http://dx.doi.org/10.1002/ana.24227

LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures. Duan, Q., Flynn, C., Niepel, M., Hafner, M., Muhlich, J.L., Fernandez, N.F., Rouillard, A.D., Tan, C.M., Chen, E.Y., Golub, T.R., et al. (2014). Nucleic Acids Res. 42, W449–W460  View PDF

Opposing effects of target overexpression reveal drug mechanisms. Palmer, A.C., and Kishony, R. (2014). Nat. Commun. 5, 4296  View PDF

Analysis of growth factor signaling in genetically diverse breast cancer lines. Niepel, M., Hafner, M., Pace, E.A., Chung, M., Chai, D.H., Zhou, L., Muhlich, J.L., Schoeberl, B., and Sorger, P.K. (2014). BMC Biol. 12, 20  View PDF

Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis. Kallenberger, S.M., Beaudouin, J., Claus, J., Fischer, C., Sorger, P.K., Legewie, S., and Eils, R. (2014). Sci. Signal. 7, ra23  View PDF