This list is growing rapidly – check back for updates
Peter K. Sorger, Director
Peter Sorger is a Professor in HMS Dept. of Systems Biology and MIT Department of Biological Engineering. His laboratory uses experimental, computational and pharmacological methods to study mammalian signal transduction networks in cancer and inflammatory disease.
Tim Mitchison, Deputy Director
Timothy J. Mitchison is a Professor in HMS Dept. of Systems Systems Biology who studies the spatial organization of microtubules and actin filaments and has been at the forefront of using novel optical methodologies to understand drugs that affect the cytoskeleton.
Vishal S. Vaidya, Head of the LSP Systems Toxicology Program
Vishal S. Vaidya is an Assistant Professor of Medicine and Environmental Health at Harvard Medical School and Harvard School of Public Health who studies and evaluates biomarkers for early detection of kidney injury; Vishal also directs a the course Principles of Toxicology-Molecular and Translational Toxicology at Harvard School of Public Health.
Marc Kirschner, Founding Chair of Systems Biology
Dr. Kirschner is founding chair of the Department of Systems Biology and John Franklin Enders University Professor of Systems Biology. Dr. Kirschner¹s laboratory investigates: regulation of the cell cycle, the role of cytoskeleton in cell morphogenesis, and mechanisms of establishing the basic vertebrate body plan.
Dr. Lahav is a Professor of Systems Biology at Harvard Medical School. Her lab uses mathematical modeling and imagine to study cellular dynamics with a particular focus on the p53 tumor supressor.
Dr. Loscalzo is the Hersey Professor of the Theory and Practice of Physic at Harvard Medical School, Chairman of the Department of Medicine and Physician-in-Chief at Brigham and Women’s Hospital, and Vice Director of the Brigham Biomedical Research Institute. Currently, his lab is chiefly interested in the vascular biology of endothelial cells and platelets.
Dr. Shah is an Associate Professor of Systems Biology and Director of the Laboratory for Cellular Systems Biology and Molecular Imaging in the Renal Division at Brigham and Women’s Hospital. His lab applies advanced approaches in photonics, imaging and computational modeling to better understand cellular dynamics and the cell cycle.
Dr. Gygi is a Professor of Cell Biology at Harvard Medical School. Dr. Gygi is a pioneer in mass spectrometry-based proteomics. His contributions to phosphorylation and then ubiquitylation analysis have revolutionized the study of these modifications. Currently, Dr. Gygi spends all of his time creating and optimizing multiplexing strategies.
Dr. Rubin is a Professor of Stem Cell and Regenerative Biology at Harvard University and a Director of Translational Medicine of the Harvard Stem Cell Institute. Much of his effort is devoted to identifying therapeutics for orphan neural disorders such as Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis, using new kinds of stem cell-based screens. His lab is also interested in methods of reversing aging-associated neurodegeneration.
Dr. Marks is an Assistant Professor of Systems Biology. She is a computational biologist interested in how to read the genome and interpret its variation. Recently, she has used evolutionary couplings determined from genomic sequencing to accurately protein 3D structure from sequences alone, including the experimentally challenging transmembrane proteins. Her lab aims to predict alternative conformations and plasticity of proteins, and the consequences of protein genetic variation on pharmacological intervention.
Dr. Silver is a Professor of Systems Biology. The Silver Lab works at the interface between systems and synthetic biology to design and build biological systems in both mammalian and prokaryotic cells. Some current projects include analysis of cells that remember past events, cell-based computation and therapeutics, and metabolic engineering for bio-energy and sustainability.