HiTS Seminar: Matthew Vander Heiden, 10:00 am, Thursday, April 18, 2019
Associate Professor of Biology and Associate Director
The Koch Institute of Integrative Cancer Research at MIT
Metabolic Constraints of Cell Proliferation
Complex regulatory mechanisms enable cell metabolism to match physiological state. The major pathways cells use to turn nutrients into energy and to synthesize macromolecules have been elucidated; however, there remain many unanswered questions regarding how metabolism supports cell proliferation and thus how best to target metabolism for cancer treatment. We have found that the redox state of the cell determines whether cells can produce oxidized biomass and support cell proliferation. We also find that both cell intrinsic and cell extrinsic factors can influence which nutrients are limiting for proliferation in different contexts. This explains some cancer metabolism phenotypes such as the Warburg effect, and suggests how different cancers can be differentially sensitive to inhibition of specific metabolic enzymes. How cell intrinsic factors cooperate with extrinsic metabolic inputs to influence tumor progression will be discussed in the context of how best to exploit altered metabolism to treat cancer.
10:00 am – 11:00 am
Thursday, April 18, 2019
Harvard Medical School
200 Longwood Avenue
Warren Alpert Bldg, 5th Floor, Room 563
Boston, MA 02115
Hosted by Chris Chidley, Ph.D.