HiTS Annual Symposium

Friday December 8, 2017         8:30am-6:45pm        

Novartis Institutes for BioMedical Research

250 Massachusetts Ave, Cambridge MA 02138

Download Electronic Program Book (PDF)


8:30 – 9:00 Registration and Light Breakfast

9:00 – 9:30 Welcome Remarks: Peter Sorger, Head of Harvard Program in Therapeutic Science, Harvard Medical School

9:30 – 10:20 Keynote Presentation: Mark Borowsky, Executive Director of Scientific Data Analysis, Novartis Institutes for BioMedical Research
Machine Learning and Drug Discovery

10:20 – 12:15 Session 1: Biology and Pharmacology at the Single Cell Level
Chair: Michael Baym
Bree Aldridge, Assistant Professor, Tufts University
Mycobacterial cell size control and antibiotic susceptibility
Ben Izar, Instructor, Harvard Medical School
Cancer cell-autonomous mechanisms of resistance to immune checkpoint inhibitors revealed by single-cell RNA-sequencing
Adam Palmer, Postdoctoral Fellow, Harvard Medical School
Identifying the origins of benefit in combination cancer therapy
Bill Forrester, Senior Research Investigator, Novartis Institutes for BioMedical Research
A regulated ubiquitin catastrope
Sandro Santagata, Assistant Professor, Dept. of Pathology, Brigham and Women’s Hospital
High dimensional pathology for clinical research

12:15 – 1:20 Lunch

1:20 – 2:40 Session 2: Computation and Data Science in Biomedicine
Chair: Bree Aldridge
Adam Riesselman, Graduate Student, Harvard Medical School
Predicting the effects of mutations with deep generative models
Toufiq Parag, Research Scientist, Harvard John A. Paulson School of Engineering and Applied Sciences
EM Connectomics : Discovering the biological neural network of animal brain
Artem Sokolov, Director of Modeling and Informatics, Laboratory of Systems Pharmacology, Harvard Medical School
Towards integration of single-cell data

2:40 – 4:30 Session 3: Measuring and Modeling Therapeutic Responses
Chair: Sandro Santagata
Leonid Peshkin, Lecturer on Systems Biology, Harvard Medical School
Bayesian Confidence Intervals for Multiplexed Proteomics
Kris Sarosiek, Assistant Professor of Radiation Biology, Harvard T.H. Chan School of Public Health
Dynamic regulation of apoptosis in healthy tissues as a driver of therapy-associated toxicities
Michael Baym, Assistant Professor of Biomedical Informatics, Harvard Medical School
Evolutionary approaches to antibiotic resistance
Steve Rodriguez, Instructor in Neurology, Massachusetts General Hospital
Neurodegeneration mediated by a neuronal antiviral innate immune signaling pathway

4:30 – 5:15 Session 4: Cheminformatics and Computational Chemistry (Discussion)
Moderator: Peter Sorger
Jeremy Jenkins, Novartis Institutes for BioMedical Research
Cheminformatics in phenotypic drug discovery
Nienke Moret, Graduate Student, Harvard Medical School
Jeremy Muhlich, Director of Software Engineering, Laboratory of Systems Pharmacology, Harvard Medical School
Building cheminformatics tools and resources for LSP

5:15 – 6:45 Poster Session, Poster Prizes and Refreshments