HiTS Annual Symposium

Wednesday, December 5, 2018

Harvard Business School, Spangler Auditorium

Soldiers Field Road, Boston, MA 02163

Download Electronic Version of Program Book


8:30 – 9:00 Registration and Light Breakfast

9:00 – 10:30 Welcome and Special Session: Oncology as a Test Bed for Precision Medicine
Chair: Cheryl Hutt, Senior Manager of Administration and Finance, Harvard Program in Therapeutic Science
Peter Sorger, Head of Harvard Program in Therapeutic Science, Harvard Medical School
A Systematic Approach to Pharmacology
H. Kim Lyerly, George Barth Geller Professor, Duke University
Accelerating Drug Development for Molecular Subsets, Rare, and Pediatric Cancers
Russ Jenkins, MGH Cancer Center and LSP Termeer Investigator, Harvard Medical School
Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

10:40 – 11:50 Session 1: Informatics and Data Analysis
Chair: Artem Sokolov, Director of Modeling and Informatics, Harvard Medical School
Anupam Jena, Ruth L Newhouse Associate Professor in Health Care Policy and Medicine, Harvard Medical School
Natural Experiments in Health Care
Clarence Yapp, LSP, IDAC, Harvard Medical School
Image Processing and Segmentation for CyCIF Data
Denis Schapiro, LSP Fellow, Harvard Medical School, Broad Institute
histoCAT: Analysis of Cell Phenotypes and Interactions in Multiplex Image Cytometry Data

11:50 – 12:45 Session 2: Regulatory Science: Challenges and Opportunities in the 21st Century
Chair: Ariel Stern, Assistant Professor of Business Administration and Hellman Faculty Fellow, Harvard Business School
Sebastian Schneeweiss, Vice Chief, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham & Women’s Hospital
Tony Letai, Professor of Medicine, Dana-Faber Cancer Institute
I Don’t Know What I Don’t Know About Regulatory Barriers for Laboratory Derived Tests

12:45 – 1:45 Lunch – Williams Room

1:45 – 3:00 Session 3: Harvard Business School: Value and Incentives in Precision Medicine Development (Panel Discussion)
Moderator: Josh Krieger, Assistant Professor of Business Administration, Harvard Business School
Richard Hamermesh, Faculty Chair, Harvard Business School Kraft Precision Medicine Accelerator
Rodrigo Martinez, Chief Marketing and Design Officer, Veritas Genetics
Ellie McGuire, Partner, Polaris Partners

3:00 – 4:15 Session 4, Part 1: Detection Methods for Biological Systems
Chair: Alyce Chen, Scientific Program Manager, Harvard Program in Therapeutic Science
Mike Springer, Harvard Medical School, Systems Biology
Microbial Movement and Biosecurity
Jeff Moffit, Boston Children’s Hospital
Mapping the Brain With in Situ Single-cell Transcriptomics

4:15 – 4:45 Session 5: Student Nano Talks
Chair: Catherine Dubreuil, Director of Education and Training, Harvard Program in Therapeutic Science
Carmen Sivakumaren, Harvard Medical School
Targeting the PI5P4K Lipid Kinase Family in Cancer Using Novel Covalent Inhibitors
Elaine Garcia, Harvard Medical School
PRL3: A Novel Oncogenic Phosphatase in T-cell Acute Lymphoblastic Leukemia
Sanchez Jarrett, Harvard Medical School
Molecular basis for feedback inhibition of Notch signaling by the Notch Regulated Ankyrin Repeat Protein, NRARP
Zebulon Levine, Harvard Medical School
Which Catalytic Activity of O-GlcNAc Transferase is Essential?

4:45 – 5:15 Session 4, Part 2: Detection Methods for Biological Systems
Chair: Alyce Chen, Scientific Program Manager, Harvard Program in Therapeutic Science
Michael Baym, Harvard Medical School, Department of Biomedical Informatics
Antibiotic Resistance Evolution

5:15 – 6:45 Poster Session, Poster Prizes and Refreshments – Williams Room