HiTS Annual Symposium

Monday, October 21, 2019
8:30am-6:00pm

Courtyard by Marriott Downtown Boston

275 Tremont Street, Boston, MA 02116

Download PDF version of the Program Book

Agenda


8:30 – 9:00 Registration and Light Breakfast

9:00 – 9:15 Welcome
Peter Sorger, Head of Harvard Program in Therapeutic Science and Otto Krayer Professor of Systems Pharmacology, Harvard Medical School

9:15 – 10:00 Session 1: Single-cell Dynamics in Cancer
Chair: Luca Gerosa, Postdoctoral Fellow, Harvard Program in Therapeutic Science, Harvard Medical School
9:15 – 9:45 Giorgio Gaglia, Postdoctoral Fellow, Department of Pathology, Brigham and Women’s Hospital
Stress adaptation and cell fate decisions mediated through HSF1 phase transition
9:45 – 10:00 Mariya Atanasova, Postdoctoral Fellow, Harvard Program in Therapeutic Science, Harvard Medical School
Characterization of short- and long-term adaptive resistance to vemurafenib in melanoma

10:00 – 10:15 Break

10:15 – 10:45 Michael Tsabar, Postdoctoral Fellow, Department of Systems Biology, Harvard Medical School
Caspase-2-PIDDosome switches p53 dynamics in cells that escape DNA damage-induced arrest
10:45 – 11:00 Jia-Yun Chen, Jane Coffin Childs Fellow, Laboratory of Systems Pharmacology and Department of Systems Biology, Harvard Medical School
Molecular dynamics of oncogenic BRaf induced senescence

11:00 – 11:30 Session 2: Student Lightning Talks
Chair: Catherine Dubreuil, Director of Education and Training, Therapeutics Graduate Program, Harvard Medical School
Sergine Brutus
High-content screening of kinase inhibitors: implications for microtubule regulation and drug discovery
Chelsea Powell
Chemically induced degradation of anaplastic lymphoma kinase (ALK)
Carmen Sindhu
Targeting the PI5P4K and PIKfyve lipid kinases in cancer using novel covalent inhibitors
Shu Wang
Spatial statistics of cell populations are governed by supercommutative mechanisms

11:30 – 1:00 Poster Session and Lunch: Washington Ballroom

1:00 – 2:45 Session 3: Informatics and Modeling
Chair: Artem Sokolov, Director of Modeling, Laboratory of Systems Pharmacology, Harvard Medical School
1:00 – 1:30 Bree Aldridge, Assistant Professor, Molecular Biology and Microbiology, Tufts University
Rational design of combination therapies for TB
1:30 – 2:00 Aedin Culhane, Senior Research Scientist, Department of Biostatistics, Dana-Farber Cancer Institute
Matrix factorization for multi ‘omics data integration
2:00 – 2:15 John Bachman, Fellow in Therapeutic Science, Laboratory of Systems Pharmacology, Harvard Medical School
Accelerating biomedical discovery: Machine-assisted modeling
2:15 – 2:30 Benjamin Gyori, Research Associate in Therapeutic Science, Laboratory of Systems Pharmacology, Harvard Medical School
Accelerating biomedical discovery: human-machine collaboration
2:30 – 2:45 Deborah Plana, MD-PhD Student, Harvard Systems Biology Graduate Program, Harvard Medical School
Parametric fitting of clinical trial data to design novel treatment regimens in oncology

2:45 – 3:00 Break

3:00 – 3:50 Session 4: Drug Assessments in Regulatory Science
Chair: Florence Bourgeois, Co-Director of the Harvard-MIT Center for Regulatory Science and Associate Professor of Pediatrics, Harvard Medical School
3:00 – 3:25 Qais Hatim, Computer Scientist, Center for Drug Evaluation and Research, US Food and Drug Administration
Using systems pharmacology approach to determine potential pharmacodynamic drug-drug interactions that may cause hepatotoxicity
3:25 – 3:50 Brian Alexander, Chief Medical Officer, Foundation Medicine
Evidence generation and application in precision medicine

3:50 – 5:20 Session 5: Relevance to Human Disease
Chair: Jennifer Guerriero, Instructor, Harvard Medical School and Director, Breast Tumor Immunology Lab, Dana-Farber Cancer Institute
3:50 – 4:20 Kevin Wei, Instructor in Medicine, Brigham and Women’s Hospital
Defining pathogenic cell states in rheumatoid arthritis by single cell profiling
4:20 – 4:50 David Liu, Instructor in Medicine, Dana-Farber Cancer Institute
Dissecting evolution of immunotherapy resistance in a melanoma exceptional responder
4:50 – 5:05 Rumana Rashid, Research Associate, Laboratory of Systems Pharmacology, Harvard Medical School
Viewing and sharing high-dimensional multiplexed data for studying human disease
5:05 – 5:20 Jennifer Guerriero, Instructor, Harvard Medical School and Director, Breast Tumor Immunology Lab, Dana-Farber Cancer Institute
Relevance to human disease

5:30 – 6:30 Poster Session, Poster Prizes and Refreshments: Washington Ballroom