News & Events Archive

HiTS Seminar: Jason Sheltzer, 10:00 AM, Thursday, January 16, 2020 January 14, 2020 -   Jason Sheltzer, PhD Cold Spring Harbor Laboratory, NY Genetic approaches to improve the characterization of anti-cancer drugs 97% of drug-indication pairs that are tested in clinical trials in oncology never advance to receive FDA approval. While lack of efficacy and dose-limiting toxicities are the most common causes of trial failure, the reason(s) why so […]
HiTS Seminar: James Kirkland, MD, PhD 10:00 AM, Thursday, December 19, 2019 January 10, 2020 - James Kirkland, MD, PhD Noaber Foundation Professor of Aging Research Director, Mayo Clinic Kogod Center on Aging, Rochester, MN, USA Aging, Chronic Disease, and Senolytic Agents   Fundamental aging processes including cellular senescence appear to make a “root cause” contribution to multiple chronic diseases, geriatric syndromes, and loss of physiological resilience. Interventions targeting aging processes […]
HiTS Seminar: Sinem Saka, PhD, 10:00 am, Thursday, September 19, 2019 September 5, 2019 -   Sinem Saka, Ph.D. Wyss Institute for Bioinspired Engineering Harvard University   Multiplexed and amplified protein imaging in tissues by Immuno-SABER   Mapping the molecular composition of individual cells in their native environment is critical to understand the cellular and subcellular organization of tissues in healthy and diseased states. However, conventional fluorescence imaging methods offer […]
HiTS Seminar: Keith Flaherty, MD, 10:00 am, Thursday, May 16, 2019 May 2, 2019 -   Keith Flaherty, M.D. Director of Clinical Research, Massachusetts General Hospital Professor of Medicine, Harvard Medical School   Determinants of response and resistance to targeted therapies and immunotherapy in melanoma   Significant therapeutic advances have been made in advanced melanoma over the past decade. For almost half of melanoma patients, BRAF inhibitor-based therapy has provided […]
HiTS Seminar: Christina Leslie, 10:00 am, Thursday, May 2, 2019 April 26, 2019 -   Christine Leslie, Ph.D. Associate Member, Computational Biology Program Sloan Kettering Institute   Decoding Epigenetic States of Immune and Cancer Cells   Dysregulated epigenetic programs are a feature of many cancers, and the diverse differentiation states of immune cells as well as their dysfunctional states in tumors are in part epigenetically encoded.  We will present […]
Using a Promiscuous Inhibitor to Uncover Cancer Drug Targets April 4, 2019 - American Society for Biochemistry and Molecular Biology Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells. When signaling pathways within cells are triggered, proteins activate through a chain reaction, like a row of tumbling dominoes, […]
HiTS Seminar: Matthew Vander Heiden, 10:00 am, Thursday, April 18, 2019 April 3, 2019 -   Matthew Vander Heiden, M.D., Ph.D. Associate Professor of Biology and Associate Director The Koch Institute of Integrative Cancer Research at MIT   Metabolic Constraints of Cell Proliferation   Complex regulatory mechanisms enable cell metabolism to match physiological state. The major pathways cells use to turn nutrients into energy and to synthesize macromolecules have been […]
HiTS Seminar: Elias Bareinboim, 10:00 am, Thursday, March 21, 2019 March 11, 2019 -   Elias Bareinboim, Ph.D. Purdue University   Causal Inference and Fusion   Causal inference is usually dichotomized into two categories, experimental (Fisher, Cox, Cochran) and observational (Neyman, Rubin, Robins, Dawid, Pearl) which, by and large, are studied separately. Understanding reality is more demanding. Experimental and observational studies are but two extremes of a rich spectrum […]
HiTS Seminar: David Feldman, 10:00 am, Thursday, January 17, 2019 December 21, 2018 -   David Feldman Broad Institute, Cambridge, MA   Scalable Image-based Genetic Screens   Genetic screens (e.g., CRISPR loss-of-function, ORF gain-of-function) provide a powerful means to identify genes underlying cellular processes. A wide range of cell behaviors can be observed by imaging assays, including dynamic responses from the scale of minutes to generations. However, image-based screens […]
HiTS Seminar: Luke Lee, PhD, 10:00 am, Tuesday, November 20, 2018 November 8, 2018 -   Luke Lee, Ph.D. University of California, Berkeley   Ultrafast Photonic PCR and Organoids on Chip   10:00 am – 11:00 am Tuesday, November 20, 2018 Harvard Medical School 200 Longwood Avenue Warren Alpert Bldg, 5th Floor, Room 563 Boston, MA 02115 Hosted by Peter Sorger, Ph.D.
HiTS Seminar: Nathanael Gray, PhD, 10:00 am, Thursday, October 11, 2018 October 4, 2018 -   Nathanael Gray, Ph.D. Dana-Farber Cancer Institute   Targeted Protein Degradation as a New Drug Development Strategy   10:00 am – 11:00 am Thursday, October 11, 2018 Harvard Medical School 200 Longwood Avenue Warren Alpert Bldg, 5th Floor, Room 563 Boston, MA 02115 Hosted by Kenichi Shimada, Ph.D.
HiTS Seminar: Dave Mellert, PhD, 10:00 am, Thursday, September 20, 2018 September 7, 2018 -   Dave Mellert, Ph.D. The Jackson Laboratory   Data Management for Data Science at The Jackson Laboratory Research data are usually collected with a specific question in mind and are thus most often managed and stored in a manner that makes reuse difficult or impossible. At the same time, the world is seeing an explosion […]
Ben Gyori named 2018 DARPA Riser September 6, 2018 - Benjamin M. Gyori, Ph.D., A Research Scientist in Therapeutic Science was selected as one of 50 DARPA Risers: up and coming early career investigators with the potential to perform innovative research at the frontiers of science and technology relevant to the mission of DARPA. As a DARPA Riser, Ben will attend DARPA’s 60th Anniversary Symposium […]
New NSF awards support the creation of bio-based semiconductors July 24, 2018 - Semiconductor synthetic biology promises to exceed limits of current data storage and processing methods Dr. Eduardo Sontag (Harvard Medical School Laboratory of Systems Pharmacology (LSP) Member, professor of Bioengineering and Electrical and Computer Engineering at Northeastern University) has been awarded, in collaboration with Dr. Chris Voigt from MIT and Dr. Kate Adamala from the University […]
HiTS Seminar: Stuart Schreiber, PhD, 10:00 am, Thursday, May 17, 2018 May 7, 2018 -   Stuart Schreiber, Ph.D. Broad Institute and Harvard University   Chemical Biology-based Approach to Understanding and Overcoming Resistance of Cancers to Therapies The ability of cancer cells to resist apoptotic death induced by radiation, chemotherapy, targeted therapies and immunotherapy has been a primary impediment to achieving long-lasting clinical responses. Cancer resistance is often studied through […]
HiTS Seminar: Bissan Al-Lazikani, PhD, 10:00 am, Tuesday, March 20, 2018 March 15, 2018 - Bissan Al-Lazikani, PhD Head of Data Science, Institute of Cancer Research, UK   Integrative Big Data for Cancer Drug Discovery and Individualised Therapy Advances in technology are enabling unprecedented systematic mapping of disease mechanisms. To fully exploit this wealth of knowledge in advancing cancer therapy, we must develop integrative ‘Big Knowledge’ approaches to inform drug […]
HiTS Seminar: Neal Rosen, MD, PhD, 11:00 am, Thursday, February 8, 2018 February 1, 2018 - Neal Rosen, MD, PhD Memorial Sloan Kettering Cancer Center Mutant Allele-specific Oncoprotein Function – Basic and Translational Implications 11:00 am – 12:00 pm Thursday, February 8, 2018 Harvard Medical School 200 Longwood Avenue Warren Alpert Bldg, 5th Floor, Room 563 Boston, MA 02115
Combination Rethink: “Bet Hedging” Explains the Efficacy of Many Combination Cancer Therapies December 14, 2017 - Benefits of many cancer drug combinations not due to interactions between drugs, but to a form of bet hedging At a glance: Survival benefits of many cancer drug combinations are not due to drug synergy, but to a form of “bet hedging.” Combination treatment gives each patient multiple chances of responding to at least one […]
HiTS Seminar: Juliet Williams and Hui Gao, 10:00 am, November 16, 2017 November 2, 2017 - Juliet Williams, Ph.D. and Hui Gao, Ph.D. Novartis Institutes of Biomedical Research 10:00 am – 11:00 am Thursday, November 16, 2017 Harvard Medical School 200 Longwood Avenue Warren Alpert Bldg, Room 563 Human Clinical Trials in Mice: Modeling Inter-patient Response Heterogeneity in PDXs Less than 10% of molecules which enter oncology trials become approved drugs. […]
Seminar by Joshua Apgar, Ph.D., 10:30am, September 14, 2017 September 7, 2017 - Joshua Apgar, Ph.D. Co-founder and CSO, Applied BioMath “Model Aided Drug Invention: Modeling Impact on Pharmaceutical R&D Applied BioMath Introduction and Case Studies” 10:30 AM Thursday, September 14, 2017 Harvard Medical School, Warren Alpert Bldg., Room 563