2017 LSP Publications

Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis. Boswell, S.A., Snavely, A., Landry, H.M., Churchman, L.S., Gray, J.M., and Springer, M. (2017). Nat. Chem. Biol. http://dx.doi.org/10.1038/nchembio.2317

Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. Tan, L., Gurbani, D., Weisberg, E.L., Jones, D.S., Rao, S., Singer, W.D., Bernard, F.M., Mowafy, S., Jenney, A., Du, G., et al. (2017a). Bioorg. Med. Chem. 25, 1320–1328 http://dx.doi.org/10.1016/j.bmc.2016.11.034

STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Durzynska, I., Xu, X., Adelmant, G., Ficarro, S.B., Marto, J.A., Sliz, P., Uljon, S., and Blacklow, S.C. (2017). Structure 25, 287–294  View PDF

Structure-guided development of covalent TAK1 inhibitors. Tan, L., Gurbani, D., Weisberg, E.L., Hunter, J.C., Li, L., Jones, D.S., Ficarro, S.B., Mowafy, S., Tam, C.-P., Rao, S., et al. (2017b). Bioorg. Med. Chem. 25, 838–846 http://dx.doi.org/10.1016/j.bmc.2016.11.035

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state. Fallahi-Sichani, M., Becker, V., Izar, B., Baker, G.J., Lin, J.-R., Boswell, S.A., Shah, P., Rotem, A., Garraway, L.A., and Sorger, P.K. (2017). Mol. Syst. Biol. 13, 905  View PDF

Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation. Jones, D.S., Jenney, A.P., Swantek, J.L., Burke, J.M., Lauffenburger, D.A., and Sorger, P.K. (2017). Nat. Chem. Biol. 13, 38–45 http://dx.doi.org/10.1038/nchembio.2211

Multiplexed Single-Cell Imaging: Past, Present, and Future. Lin, J.-R. (2017). Assay Drug Dev. Technol. 15, 8–10 http://dx.doi.org/10.1089/adt.2016.765