2017 LSP Publications
Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis. Boswell, S.A., Snavely, A., Landry, H.M., Churchman, L.S., Gray, J.M., and Springer, M. (2017). Nat. Chem. Biol. http://dx.doi.org/10.1038/nchembio.2317
Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. Tan, L., Gurbani, D., Weisberg, E.L., Jones, D.S., Rao, S., Singer, W.D., Bernard, F.M., Mowafy, S., Jenney, A., Du, G., et al. (2017a). Bioorg. Med. Chem. 25, 1320–1328 http://dx.doi.org/10.1016/j.bmc.2016.11.034
STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Durzynska, I., Xu, X., Adelmant, G., Ficarro, S.B., Marto, J.A., Sliz, P., Uljon, S., and Blacklow, S.C. (2017). Structure 25, 287–294 View PDF
Structure-guided development of covalent TAK1 inhibitors. Tan, L., Gurbani, D., Weisberg, E.L., Hunter, J.C., Li, L., Jones, D.S., Ficarro, S.B., Mowafy, S., Tam, C.-P., Rao, S., et al. (2017b). Bioorg. Med. Chem. 25, 838–846 http://dx.doi.org/10.1016/j.bmc.2016.11.035
Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state. Fallahi-Sichani, M., Becker, V., Izar, B., Baker, G.J., Lin, J.-R., Boswell, S.A., Shah, P., Rotem, A., Garraway, L.A., and Sorger, P.K. (2017). Mol. Syst. Biol. 13, 905 View PDF
Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation. Jones, D.S., Jenney, A.P., Swantek, J.L., Burke, J.M., Lauffenburger, D.A., and Sorger, P.K. (2017). Nat. Chem. Biol. 13, 38–45 http://dx.doi.org/10.1038/nchembio.2211
Multiplexed Single-Cell Imaging: Past, Present, and Future. Lin, J.-R. (2017). Assay Drug Dev. Technol. 15, 8–10 http://dx.doi.org/10.1089/adt.2016.765