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The Harvard Program in Therapeutic Science (HiTS) invites applications for a fellowship position at the Harvard-MIT Center for Regulatory Science. The fellow will work with a multidisciplinary team to develop and evaluate novel computational methods to support automated detection of drug-drug interactions in large and disparate healthcare datasets.
About the Fellowship
The Harvard-MIT Center for Regulatory Science is a partnership between Harvard, MIT and the FDA, focused on building innovative approaches for the development and evaluation of medical products. Working across academia, industry, and government institutions, the Center promotes regulatory science through research and education programs, uniting stakeholders under a common mission: promoting optimal patient health outcomes through biomedical innovation and the availability of safe and effective diagnostics and treatments. The Regulatory Science Fellows Program draws individuals of diverse experiences who are passionate about using novel applications of data science to improve the use of therapeutics in patient populations.
For this position, the Fellow will work with faculty at Harvard in the Department of Biomedical Informatics https://dbmi.hms.harvard.edu. The fellow will be based in the Avillach Lab, an interdisciplinary research group focused on the development of cutting edge techniques for the integration of multiple heterogeneous biological and clinical cohorts with the overarching goal of supporting individualized data-driven healthcare.
The application of healthcare claims data and electronic health records for use in pharmacoepidemiological studies is booming. Drug–drug interactions can be identified by mining such databases, including adverse drug reactions (ADRs) resulting from the prescription of a combination of drugs (CADRs), considered a special class of drug-drug interactions. While many ADRs can be anticipated and hence avoided, CADRs are highly complex and challenging to identify and, as a consequence, have not been well studied. CADRs may represent as many as 30 % of unexpected ADRs and their elucidation is of particular interest to the FDA. The fellowship project will develop new signal detection algorithms using data mining techniques in real-world healthcare data derived from claims and electronic healthcare records. The project will aim to identify potential pharmacovigilance signals concerning drug-drug interactions across multiple diseases and syndromes.
Research activities include, but are not limited to:
- Extract and analyze information from a nationwide claims database including 67 million subjects
- Extract and analyze information from healthcare records in an academic pediatric hospital including 1.8 million patients
- Develop and test methods to detect adverse drug reactions from billing codes, drug prescriptions and lab value results
- Disseminate findings through national and international conferences and in peer-reviewed scientific publications
- PhD in computer science, engineering or a related field
- Expertise in SQL query language
- Expertise in R or Python programing languages
Application Procedure and Requirements
Applications will be accepted until the position is filled. Please send your application to to firstname.lastname@example.org and include the following:
- Curriculum vitae
- Cover letter and a 2-page description of relevant experience as a single PDF
- DOI or PMCID of up to three relevant publications
Selected candidates will be asked to provide letters of reference.
Host Institution: Harvard Medical School
Appointing Department: Harvard Program in Therapeutic Science
Research Laboratory: Paul Avillach
Location: Boston, MA
Other responsibilities: no administrative or teaching obligations
Duration of fellowship: 2 years
Harvard Medical School is an Equal Opportunity/Affirmative Action Employer.
Women and minorities are especially encouraged to apply.
For more information contact
Paul Avillach, MD, PhD
Department of Biomedical Informatics | Harvard Medical School
Children’s Hospital Informatics Program | Boston Children’s Hospital
This free, self-paced, six-session online course will cover pharmaceutical product development, approval, marketing, and costs, as well as an overview of FDA and the major issues affecting regulatory approval and evidence-based use of prescription drugs. For more information on the course material, watch this introductory video here. The course is run by the Program on Regulation, Therapeutics, and Law (PORTAL), a CRS partner program, in conjunction with HarvardX/edX, and is currently ongoing. Register here!