We work at the convergence of science, medicine, and engineering to reinvent the process of drug discovery and treatment.
Our philosophy:
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Innovation
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Converging technologies will bring medical breakthroughs. We integrate laboratory investigation, computer science, and clinical research to develop precision approaches for diagnosing and treating disease.
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Open Sharing
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Open data drives discovery. We are committed to accelerating research by making our methods, publications, software, and datasets freely available to the broader scientific community.
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Training
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We learn better together. Our team unites people with unique perspectives and expertise to cultivate the next generation of interdisciplinary leaders.
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Translation
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Patients’ needs guide our work. Partnering with clinicians, we aim to develop and deploy novel, clinic-ready solutions that improve patient care.
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HiTS Publications
Changing fitness effects of mutations through long-term bacterial evolution
Couce and Limdi et al 2024. Science.
High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers
Lin, Chen, Campton, et al. 2023. Nature Cancer
Sequential apoptotic and multiplexed proteomic evaluation of single cancer cells
Lecky et al. 2023. Science Advances.
Association Between Regulatory Submission Characteristics and Recalls of Medical Devices Receiving 510(k) Clearance.
Everhart, et al. 2023. JAMA.
US Food and Drug Administration Approval of High-risk Cardiovascular Devices for Use in Children and Adolescents, 1977-2021.
Wunnava, et al. 2023. JAMA.
Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia
Charpignon et al. 2023. Nature Communications.
Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
Lin, Wang, Coy et al. 2023. Cell
The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution.
Nirmal et al. 2024. Cancer Discovery.